针对新的药物作用靶点进行药物设计与开发,聚焦抗感染及抗肿瘤药物开发;
多肽及蛋白质化学修饰,及抗体偶联药物开发;
新型荧光标记方法。
涵盖药物化学、计算机辅助药物设计、化学生物学、有机化学等研究领域。
讲授课程:
本科生:《药物化学实验》、《药物化学》、《药物设计与开发Ⅰ(中药及化学药)》
课题组获得国家以及环球360会员注册支持,经费充裕,实验室新近装修,热忱欢迎研究生或者博士后人员加入!
课题组最新研究成果:
(1) Direct synthesis of unnatural amino acids and modifications of peptides via LADA strategy. Chinese Chemical Letters, 2024, 35, 108553.
(2) Design and Synthesis of Novel Near-Infrared Fluorescence Probes Based on an Open Conformation of Cytochrome P450 1B1 Complex for Molecular Imaging of Colorectal Tumors. J. Med. Chem., 2023, in press.
(3) LADA strategy for the synthesis of unnatural amino acids and direct modifications of peptides. SCIENCE CHINA Chemistry, 2023, 66, 1788.
(4) Decarboxylative oxidation-enabled consecutive C-C bond cleavage. Nature Communications, 2022, 13,7061.
(5) Three-component radical homo Mannich reaction, Nature Communications, 2021, 12, 1006.
(6) Visible-light induced metal-free cascade Wittig/hydroalkylation reactions, Green Chemistry, 2021, 23: 1638.
(7) A mild, general, and metal-free method for site-specific deuteration induced by visible light
using D2O as the source of deuterium atoms, Green Chemistry, 2020, 22, 669-672.
(8) Synthesis and structure-activity relationship studies of α-naphthoflavone derivatives as CYP1B1 inhibitors. Eur. J. Med. Chem., 2020, 187, 111938.
(9) Discovery and synthesis of sulfur-containing 6-substituted 5,8-dimethoxy-1,4-naphthoquinone oxime derivatives as new and potential anti-MDR cancer agents. Eur. J. Med. Chem., 2019, 165, 160-171.
(10) Design, synthesis, and biological evaluation of cytochrome P450 1B1 targeted molecular imaging probes for colorectal tumor detection. J. Med. Chem. 2018, 61, 10901-10909.